Homology Modeling of Cysteinyl Leukotriene1 Receptor

Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer.

Leukotrienes (LTs) are biologically active fatty acids derived from the oxidative metabolism of arachidonic acid through the 5-lipoxygenase pathway. LTs work to contract airway smooth muscle, increase vascular permeability and mucus secretions, and attract and activate inflammatory cells in the airways of patients with asthma. Recently, it was reported that the LTD4 receptor (cysteinylLT1 recep...

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

Montelukast sodium [1-([(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl)cyclopropylacetic acid sodium salt] (MK-476, Singulair) is a potent and selective antagonist of the cysteinyl leukotriene (Cys-LT1) receptor and is under investigation for the treatment of bronchial asthma. To assess the metabolism and excretion of montelukast...

homology modeling of human nmda receptor and studies of the channel symmetry using brownian dynamics simulation

Homology Modeling of the Calcium Sensing Receptor Extracellular Domain

The extracellular calcium-sensing receptor (CaR) on the parathyroid cell surface negatively regulates secretion of parathyroid hormone (PTH). CaR has an important rule in diseases. Cinacalcet hydrochloride, an allosteric agonist of this receptor was approved by FDA in 2004 for treatment of secondary hyperparathyroidism. Cinacalcet is indicated for the treatment of hypercalcemia in patients with...

On homology modeling of the M2 muscarinic acetylcholine receptor subtype

Twelve homology models of the human M2 muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON). The best models were obtained using single template of the closest published structure, the M3 muscarinic receptor (PDB:4DAJ). Adding more (structurally distant) templates led to wor...